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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STAT2 All Species: 18.18
Human Site: S606 Identified Species: 50
UniProt: P52630 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52630 NP_005410.1 851 97916 S606 L L R F S E S S E G G I T C S
Chimpanzee Pan troglodytes XP_001168971 851 97916 S606 L L R F S E S S E G G I T C S
Rhesus Macaque Macaca mulatta XP_001115072 851 97734 S606 L L R F S E S S E G G I T C S
Dog Lupus familis XP_538232 854 98064 S605 L L R F S E T S E G G I T C S
Cat Felis silvestris
Mouse Mus musculus Q9WVL2 923 105399 S605 L L R F S E T S E G G I T C S
Rat Rattus norvegicus P52631 770 88021 C550 Q I T W A K F C K E N M A G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q6DV79 771 88152 K551 I T W A K F C K E N M A G K G
Frog Xenopus laevis Q7ZXK3 766 87581 W546 Y S G C Q I T W A K F C K E N
Zebra Danio Brachydanio rerio XP_693577 835 95562 K601 L R F S E S I K D G G I T F S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97 85.4 N.A. 66.5 37 N.A. N.A. 36.4 36.3 37.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 97.8 90.5 N.A. 75.8 55.2 N.A. N.A. 55.4 54.6 55.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 0 N.A. N.A. 6.6 0 40 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 40 N.A. N.A. 13.3 13.3 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 12 12 0 0 0 12 0 0 12 12 0 0 % A
% Cys: 0 0 0 12 0 0 12 12 0 0 0 12 0 56 0 % C
% Asp: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 12 56 0 0 67 12 0 0 0 12 0 % E
% Phe: 0 0 12 56 0 12 12 0 0 0 12 0 0 12 0 % F
% Gly: 0 0 12 0 0 0 0 0 0 67 67 0 12 12 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 12 12 0 0 0 12 12 0 0 0 0 67 0 0 0 % I
% Lys: 0 0 0 0 12 12 0 23 12 12 0 0 12 12 12 % K
% Leu: 67 56 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 12 12 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 12 12 0 0 0 12 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 12 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 12 56 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 12 0 12 56 12 34 56 0 0 0 0 0 0 67 % S
% Thr: 0 12 12 0 0 0 34 0 0 0 0 0 67 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 12 12 0 0 0 12 0 0 0 0 0 0 0 % W
% Tyr: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _